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Utilize other team's weaknesses-
Before you start, look at the other team's depth chart. See if there is anything you can take advantage of. For example, if your opponent has a weak secondary, especially cornerbacks, you should either use play action (fake run) or go deep a lot. Look at the secondary players' speed and awareness. If they have bad awareness use play action, if they have bad speed go deep. If your opponent has a bad offensive line, you should blitz six or seven defenders at a time and get pressure on the quarterback.
Run the ball on first down-
You should run the ball on first down because you need to get some kind of yardage on first down. This will make it a lot easier to get another first and keep the drive going. Even if you do not want to run the ball, you should at least run a pass play that is guaranteed to get you some kind of yardage.
Call wide receiver options-
This means you should use the plays that have a solid line, then a dotted line on a receiver's route. These plays are very reliable. It doesn't matter if the opposition is playing zone defense or man-to-man defense because these types of plays have two or three options. Usually the receiver has a choice of doing a button hook or running a square-out pattern. Some option plays have a third choice of running a square-in pattern.
Get comfortable with a playbook-
This is a very important thing to do because if get use to a certain playbook, you know what plays work, and what plays don't. I always use Chicago's playbook. I have been using it for five years. It is the playbook that is best for me because of my playing style. I run the ball, and I use my tight end a lot. This playbook also has a lot of wide receiver options which is how I like to play. On defense, I just use the generic 4-3 playbook.
Use your tight end on third and short-
I use this rule all the time. If you have 3rd and 6 or 3rd and 3, you should use your tight end. The tight end position runs a lot of patterns that are within four to eight yards from the line of scrimmage. You should throw to tight end on third down because most defenses will probably play zone in this situation and there will be holes in the middle of the zone for your tight end. Personally, I love to use a tight end option play because it is very reliable.